Effect of Celecoxib and Diclofenac on Blood Pressure, Renal Function and Vasoactive Prostanoids in Young Early Subjects

Objective: Determination of celecoxib and diclofenac effects in early young subjects. Study design: Randomized study designed Methodology: All the participants received 225 mg two times/day 80mg times/day. First 21 days all treatment, before start following medicine 3.5 weeks gap was given. The blood pressure (BP) patients measured using ambulatory monitoring device (space labs model 90217A). Results: Group one consisted had a mean ± SD age 29 3.4 while group 2 elderly 55 5.5. body mass index (group 1) 21.7 1.8 kg/m2 for = 27.3 1.0 kg/m2. 5 (38.46%) females 8 (61.53%) males 4 (30.76%) 9 (69.23%) males. medication baseline BP shows that there no significant difference found systolic pressure. Similar results diastolic (mm Hg) day night time. Mean arterial higher -2 than 1, Plasma renin activity less on compared to 1. concentration were decreased after 7 treatment. A non-significant result obtained. 1 Aldosterone serum (ng/l) 11 2.2 value one, 13.2 3.2, 14 14.2 3.4. Similarly case diclofenac, 11.3 21, 7= 12.2 2.3, 12.3 2.1. decrease values observed both groups aldosterone serum. For group-2 celecoxib, one=15 2.2, 2.4*. day14= 1.4. 15 7day= 1.5, 5.1. comparison sodium potassium treatments groups. Conclusion: Overall, we got response drugs renal function Keywords: pressure, angiotensin system, non-steroidal anti-inflammatory (NSAIDs)